Faculty

Charles F. Reynolds III and Ellen G. Detlefsen Endowed Chair in Geriatric Psychiatry
Research Focus:

Cellular and Molecular Basis of Neurodegeneration

Chief, Division of Pediatric Nephrology, Children’s Hospital of Pittsburgh of UPMC
Research Focus:
  • Role of FGF Receptors in the Developing Kidney
  • Genetic Model of Urogenital Development and Obstruction
  • Role of fibroblast growth factor receptors (Fgfrs) in embryonic kidney development using conditional knockout mouse models
  • A genetic model of vesicoureteral reflux and reflux nephropathy, generated by deletion of Fgfr2 in kidney mesenchyme
  • A genetic model of obstructive nephropathy in a transgenic insertional mutant
  • Genetics of congenital kidney diseases in children
Academic Chief, Pediatric Critical Care Medicine
Research Focus:

Primary themes of mitochondrial injury and oxidative stress

Director, Graduate Program in Immunology & Microbiology
Research Focus:

Mechanisms of cross-priming of antigens during immune responses to cancer, viruses and autoimmunity

Associate Director of the Program in Microbiology and Immunology (PMI) graduate program
Research Focus:

The Bomberger lab is exploring the mechanistic basis by which acute viral infections promote the development of chronic bacterial infections and shapes microbial communities in the respiratory tract, particularly in the setting of chronic respiratory diseases, like cystic fibrosis (CF) and chronic rhinosinusitis (CRS).

Assistant Professor, Pediatrics and Immunology
Research Focus:

Graft versus host disease, T cell metabolism, Bone marrow transplantation for non-malignant hematopathology

Director, Center for Pulmonary Vascular Biology and Medicine
Research Focus:

Molecular mechanisms of pulmonary vascular disease and pulmonary hypertension (PH)

A. Julio Martinez Chair, Neuropathology
Research Focus:
  • Mechanisms regulating mitochondrial quality control in neurons – function, turnover (mitophagy), biogenesis, and transport
  • The autophagy-lysosomal system and calcium dysregulation in dendrite injury and neurodegeneration
  • Compartmentalized kinase signaling in familial neurodegeneration (PINK1, tau, VCP, LRRK2)
  • Mitochondrial and phospho-proteomics, post-translational mechanisms
Director, Systems Medicine Program, CRISMA Center, Department of Critical Care Medicine
Research Focus:
  • Physiological Variables to Predict Diagnose and Treat Cardiorespiratory Instability
  • Computational Analysis of Noninvasive Ventilation
  • Detecting deviations in clinical care in ICU data streams
  • Quantitative Model-Based Medical Decision Support by Bayesian Inference
  • Computational Models of Infectious Disease Threats
Assistant Professor, Division of Hematology/Oncology
Research Focus:

Ovarian cancer microenvironment, understanding and targeting the cancer-supporting stromal tissues which are critical to the survival, growth and spread of ovarian cancer.

Associate Professor, Pediatrics and Microbiology and Molecular Genetics
Research Focus:

Host-pathogen interactions; Innate Immune Signaling

Vira I. Heinz Professor and Chair, Department of Pediatrics
Research Focus:
  • Viral replication and pathogenesis
  • Reovirus and celiac disease
  • Vaccine development
Chief, UPMC Newborn Medicine Program
Research Focus:
  • Neonatal and Pediatric Platelet Function and Pharmacology
  • Analysis of Platelet Function and MicroRNA-mRNA Profiles in Neonatal Cardiac Patients
  • Bayer Phase I/II clinical study on the safety, efficacy, PK, and PD of oral rivaroxaban for catheter-related thrombosis in neonates
  • Preclinical and Clinical Evaluation of Protein Kinase Inhibitors on Platelet Function
  • Precision Medicine in the Diagnosis of Genetic Disorders in Neonates
Director, Center for Innovative Antimicrobial Therapy
Research Focus:

Mechanism of antimicrobial resistance in Gram-negative bacteria

Associate Professor, Psychiatry
Research Focus:

Reinforcement learning; Decision-making in suicidal behavior; Borderline personality disorder

Chief, Division of Lung Transplant/Lung Failure
Research Focus:
  • Molecular mechanisms of non-small cell lung cancer tumorigenesis
  • Novel therapeutics for non-small cell lung cancer
  • Micrometastases and their potential biological significance in non-small cell lung cancer
  • Bronchial artery infusion of chemotherapeutic agents as a novel therapy for lung cancer
Director of the Sleep and Schizophrenia Program, Department of Psychiatry
Research Focus:

Neurobiology of schizophrenia; Sleep regulation in health and disease; Neuroplasticity and non-invasive brain stimulation

G. Nicholas III and Dorothy B. Beckwith Endowed Chair in Translational Medicine
Research Focus:

Aging, mitochondrial function, cellular metabolism, cardiovascular disease

Assistant Professor, Psychiatry and Cell Biology
Research Focus:

Schizophrenia; Antipsychotic drug action; Metabolism; Neurodegeneration; Dopamine signaling

Richard L. Simmons Professor of Surgery
Research Focus:

Liver cancer cell signaling and hepatic I/R injury

Jack D. Myers Professor and Chair, Department of Medicine
Research Focus:
  • The nitrite anion is a circulating storage pool for NO bioactivity that regulates hypoxic vasodilation and the cellular resilience to low oxygen and ischemia
  • A novel physiological function for hemoglobin as an electronically- and allosterically-regulated nitrite reductase
  • The characterization of a novel mechanism of disease, hemolysis-associated endothelial dysfunction
  • The mechanistic, clinical, and epidemiological description of a human disease syndrome, hemolysis-associated pulmonary hypertension.
Co-Director, Pediatric Scientist Development Program
Research Focus:

The role of microRNAs (miRNAs) in kidney development and disease

Director of the Exocrine Pancreas Center at the Children’s Hospital of Pittsburgh of UPMC
Research Focus:
  • The crucial signaling pathways that initiate and transduce pancreatitis
  • The factors that turn on pancreatic regeneration and recovery after pancreatic injury
  • The mechanisms underlying specific forms of drug-induced pancreatitis (DIP).
Director of the Cutaneous Biology Research Core
Research Focus:
  • Development of innate and adaptive responses to epicutaneous C. albicans infection
  • Relationship of pain-sensing neurons in the skin with host defense
  • The ability of keratinocytes to retain dendritic cells and T cells in the epidermis
  • Development of humoral responses to cutaneous pathogens
  • Plasticity of individual skin-resident dendritic cell subsets
  • Tolerance and suppression of immune responses by Langerhans cells
Chief of the Division of Endocrinology and Metabolism
Research Focus:

Pathogenesis and treatment of obesity and related metabolic disorders

Chief, Renal-Electrolyte Division
Research Focus:

Epithelial transport physiology. We are examining mechanisms by which external factors, including Na+, proteases, and shear stress, regulate the activity of epithelial Na+ channels.

Director of Research in Cardiology at the University of Pittsburgh School of Medicine, Children’s Hospital of Pittsburgh of UPMC
Research Focus:
  • Cardiomyocyte proliferation
  • Heart regeneration
Frank & Athena Sarris Chair in Transplantation Biology
Research Focus:

Fundamental mechanisms of acute and chronic rejection in solid organ transplantation

Director, T1 Translational Research Track MS program at Institute for Clinical Research Education.
Research Focus:

Effector functions of mononuclear phagocytes (macrophages, monocytes) and neutrophils, their roles in the initiation and resolution process of injury in tissue sites such as the lungs, and their potential relevance to human disease.

Chair, Department of Psychiatry
Research Focus:

Neural circuitry of the prefrontal cortex and related brain regions, and the alterations of this circuitry in schizophrenia

Fellowship Director, Pediatric Infectious Diseases Program
Research Focus:

Our lab is focused on the host protective immune responses to M. tuberculosis (the bacterial pathogen for tuberculosis (TB), the leading factor in the outcome of infection. We are also interested in the interaction between SIV-Mtb co-infection, especially in the context of the HIV-TB global epidemic. Using a unique model of TB, we are able to follow the in vivo progression of disease using PET-CT imaging and track bacterial dissemination.

Associate Professor, Pathology and Pediatrics
Research Focus:

Relationship between chronic inflammation and the development of vascular, metabolic, and neoplastic diseases

Director of Pediatric Hematology-Oncology
Research Focus:

Signaling pathways involved in lymphomagenesis

Staunton Professor of Psychiatry and Pediatrics
Research Focus:

Brain basis underlying the transition from adolescent to adult level cognitive control (working memory, response inhibition, reward processing). fMRI, DTI, PET, MRSI and cognitive testing are used

Professor of Psychiatry and Clinical and Translational Science
Research Focus:

Interested in discovering the molecular mechanisms of bipolar disorder, major depression, and drug addiction

Fellowship Director, Female Pelvic Medicine & Reconstructive Surgery, UPMC Medical Education Program
Research Focus:
  • Biomaterials used in reconstructive pelvic surgeries:  impact of current devices and the development of novel solutions
  • Defining mechanisms of maternal birth injury and optimizing repair
  • Defining mechanisms of failure after reconstructive pelvic surgeries
  • Defining novel solutions to pelvic floor failure
Samuel P. Harbison Assistant Professor of Surgery
Research Focus:

Mitochondrial dysfunction within the intestinal epithelium of patients with IBD

Distinguished and American Cancer Society Professor of Microbiology and Molecular Genetics
Research Focus:
  • Kaposi’s sarcoma-associated herpesvirus (KSHV), the viral cause of Kaposi’s sarcoma
  • Merkel  cell  polyomavirus  (MCV), the viral cause of Merkel cell carcinoma
  • Methods to search for undiscovered human tumor viruses
Director Education, Aging Institute
Research Focus:

The role of mitochondrial dysfunction in the pathogenesis of idiopathic Pulmonary Fibrosis (IPF), a highly lethal age-related lung disease. 

Associate Professor of Surgery and Human Genetics
Research Focus:

Pathogenicity of Intestinal Microbes in Milk Fed and Formula Fed Premature Infants

Interim Division Chief, Pulmonary, Allergy, and Critical Care Medicine, UPMC Chair of Translational Pulmonary and Critical Care Research
Research Focus:

Translational research on HIV-associated pulmonary disease as well as on the role of the microbiome in pulmonary-related diseases

Chief of the Division of Pediatric Endocrinology
Research Focus:
  • Regulators of glucose metabolism
  • GH/IGF axis on glucose and energy homeostasis
  • Role of the hypothalamus in whole body energy and glucose metabolism
  • Novel mitochondria-associated peptides
Roberta G. Simmons Endowed Assistant Professor of Surgery Departments of Surgery and Critical Care Medicine
Research Focus:
  • Trauma-induced coagulopathy and hemostasis following trauma and hemorrhagic shock
  • Measurement of coagulopathy in trauma and sepsis
  • Clinical outcomes in trauma/hemorrhagic shock
  • Clinical outcomes in massive transfusion
  • Immunomodulation and transfusion of red blood cells
  • Acute care surgery outcomes research and surgical rescue
  • Outcomes research focusing on emergency general surgery, elective abdominal wall reconstruction, and surgical rescue
Director, Program for Genetics and Psychosis
Research Focus:

Treatment and rehabilitation for psychoses

Associate Professor of Medicine
Research Focus:

Assessment of the pulmonary complication of obesity and metabolic syndrome.

Director, Fertility Preservation Program of UPMC
Research Focus:

Stem cells, germ lineage development, fertility and infertility

Associate Professor of Pediatrics, Human Genetics & Neurology
Research Focus:

Cellular and molecular basis of human neurodegenerative diseases

Assistant Professor, Psychiatry
Research Focus:

Depression; Mechanisms of treatment response & placebo effects; Functional and molecular neuroimaging

Pittsburgh Foundation-Emmerling Endowed Chair in Psychotic Disorders
Research Focus:

The use of multimodal neuroimaging techniques to elucidate functional and structural abnormalities in emotion processing, reward processing and emotional regulation circuitries that are associated with specific psychiatric disorders, and symptom dimensions in individuals with mood and anxiety disorders

Director of Oncology Research, UPMC Children’s Hospital of Pittsburgh
Research Focus:
  • Evaluation of molecular inhibitors of the c-myc oncoprotein
  • Regulation of and by the Myc oncoprotein
  • Function and pharmacologic regulation of the c-Myc oncoprotein
  • Impact of c-Myc oncoprotein expression on cellular metabolism
Site Chief of Vascular Services, Magee-Womens Hospital of UPMC
Research Focus:

Dr. Sachdev-Ost’s research has focused on the role of danger signaling, toll-like receptors (TLRs) and autophagy in regulating recovery from ischemic muscle injury.  This work has potential implications in patients with peripheral vascular disease. Recently, she has also been studying growth and functional characteristics of muscle satellite cells that are harvested from patients with PAD, to determine whether they can be used in therapeutic applications. Finally, she is also studying the role of inflammation in patients with chronic venous insufficiency.

Executive Director, Magee-Womens Research Institute
Research Focus:

Placental biology, seeking to decipher the molecular mechanisms underlying placental dysfunction, which impacts pregnancy and impedes fetal growth with devastating consequences to the mother and newborn

Director of Graduate Education for Surgery Research
Research Focus:
  • The role of the inflammasome and caspase-1 in trauma and hemorrhage
  • The role of the inflammasome and caspase-1 in sepsis
  • Inflammasome activation and metabolic control in the liver and during surgery
Director, Nitric Oxide Metabolomics Core Facility
Research Focus:
  • Redox Biology
  • Signal Transduction
  • Translational Biomarkers
  • Biochemical and Molecular Pharmacology
Professor and Chair, Immunology
Research Focus:

B cell immune response and how the immune system is activated in systemic autoimmunity leading to pathogenesis

Professor and Gerald E. McGinnis Chair in Bioengineering
Research Focus:

Myocardial proteins and whole heart mechano-energetic function; Vascular stiffness and cardiovascular function; Large-scale mathematical models of biological systems

Chair, Department of Microbiology and Molecular Genetics
Research Focus:

Role of protein-tyrosine kinase signaling pathways in cancer, HIV/AIDS, and embryonic stem cell differentiation. Our research program is interdisciplinary, integrating techniques of chemical genetics, biochemistry, molecular biology and biophysics to gain insight into the role of kinase signaling pathways in ES cell fate, cancer and AIDS

Tenured Professor and Chair of Physical Medicine & Rehabilitation
Research Focus:

Active research program investigating the role of mechanical forces in disc degeneration

Associate Dean, Director Medical Scientist Training Program
Research Focus:

Cancer Pharmacology

UPMC Professor of Psychiatric Neuroscience and Professor of Neurology
Research Focus:

Neurobiological mechanisms underlying the occurrence of psychotic symptoms, delusions and hallucinations

Chief of Vascular Surgery, VA Pittsburgh Healthcare System
Research Focus:
  • Vasoprotective functions of carbon monoxide and nitrite/nitrate in vascular injury
  • Innate immunity and danger signals in angiogenesis and vascular injury
  • Role of carbon monoxide and nitrite/nitrate in wound healing and aortic aneurysm formation
  • Translation of inhaled carbon monoxide and dietary nitrite/nitrate to clinical application through clinical trials of post-stenting restenosis
Vice Chair for Pre-Clinical Research
Research Focus:

Translational cardiovascular research

Chief, Division of Medical Genetics
Research Focus:
  • Mitochondrial architecture of mitochondrial metabolism
  • Molecular and functional characterization of inborn errors of fatty acid oxidation and branched chain amino acids
  • Development of novel therapeutic agents for inborn errors of metabolism
  • Characterization of a knock out porcine model for phenylketonuria
Associate Professor, Psychiatry
Research Focus:

Disruptions in prenatal ontogeny in cortical parvalbumin neuron dysfunction in schizophrenia

Professor of Medicine and of Cell Biology, and Clinical and Translational Science
Research Focus:

Regulation of kidney proximal tubule dynamics and function

Executive Vice-Chairman of the Section of Laboratory Medicine
Research Focus:

Aims to understand cell responses in the context of tissue and organismal biology

Director, University of Pittsburgh Asthma Institute @ UPMC
Research Focus:

Pioneered the concept of asthma phenotypes, including the progression to molecular phenotyping

Henry L. Hillman Endowed Chair in Pediatric Immunology
Research Focus:

Clinical and basic investigation of human respiratory viruses

Associate Professor, Obstetrics and Gynecology
Research Focus:
  • Genome Integrity
  • Meiotic crossover formation
  • Germline aging and infertility
  • DNA double-strand break repair pathways
  • Germ cell fate specification
Chief, Division of Trauma and General Surgery.
Research Focus:
  • Investigations into the protective responses within the liver that limit injury in response to hemorrhage or sepsis
  • Vascular injury and pulmonary arterial hypertension