Fadi Lakkis, MD

  • Frank & Athena Sarris Chair in Transplantation Biology
  • Scientific Director of the Thomas E. Starzl Transplantation Institute
  • Professor of Surgery, Immunology and Medicine

Education & Training

  • Medical School – American University of Beirut, Lebanon - MD

Research Grants

NIH Grants:  R01, R29, U19

Research Summary

Innate and adaptive immune response to transplanted organs and the mechanisms of transplantation tolerance.

Dr. Lakkis studies innate mechanisms responsible for initiating and perpetuating alloimmune responses and the role of memory T cells in allograft rejection. Mouse models of skin, heart, kidney, and islet cell transplantation are used to define these mechanisms. Intravital multiphoton microscopy is used to investigate monocyte and memory T cell migration to the transplanted mouse kidney. Dr. Lakkis is committed to scientific mentoring. His lab offers a superb environment for pediatric subspecialists in many fields, including Solid Organ and Bone Marrow Transplantation, Hematology-Oncology, Immunology, Nephrology, and Pulmonary Medicine.

Representative Publications

  1. Hughes AD, Lakkis FG, Oberbarnscheidt MH. Four-Dimensional Imaging of T Cells in Kidney Transplant Rejection. J Am Soc Nephrol. 2018 Jun;29(6):1596-1600. doi: 10.1681/ASN.2017070800. Epub 2018 Apr 13. PubMed PMID: 29654214; PubMed Central PMCID: PMC6054351.
  2. Thomson AW, Humar A, Lakkis FG, Metes DM. Regulatory dendritic cells for promotion of liver transplant operational tolerance: Rationale for a clinical trial and accompanying mechanistic studies. Hum Immunol. 2018 May;79(5):314-321. doi: 10.1016/j.humimm.2017.10.017. Epub 2017 Oct 31. Review. PubMed PMID: 29100944; PubMed Central PMCID: PMC5924712.
  3. Dai H, Friday AJ, Abou-Daya KI, Williams AL, Mortin-Toth S, Nicotra ML, Rothstein DM, Shlomchik WD, Matozaki T, Isenberg JS, Oberbarnscheidt MH, Danska JS, Lakkis FG. Donor SIRPα polymorphism modulates the innate immune response to allogeneic grafts. Sci Immunol. 2017 Jun 23;2(12). pii: eaam6202. doi: 10.1126/sciimmunol.aam6202. PubMed PMID: 28783664; PubMed Central PMCID: PMC5653256.
  4. Lakkis FG, Li XC. Innate allorecognition by monocytic cells and its role in graft rejection. Am J Transplant. 2018 Feb;18(2):289-292. doi: 10.1111/ajt.14436. Epub 2017 Aug 24. Review. PubMed PMID: 28722285; PubMed Central PMCID: PMC5775052.
  5. Boyette LB, Macedo C, Hadi K, Elinoff BD, Walters JT, Ramaswami B, Chalasani G, Taboas JM, Lakkis FG, Metes DM. Phenotype, function, and differentiation potential of human monocyte subsets. PLoS One. 2017 Apr 26;12(4):e0176460. doi: 10.1371/journal.pone.0176460. eCollection 2017. PubMed PMID: 28445506; PubMed Central PMCID: PMC5406034.
  6. Moore CA, Iasella CJ, Venkataramanan R, Lakkis FG, Smith RB, McDyer JF, Zeevi A Ensor CR. Janus kinase inhibition for immunosuppression in solid organ transplantation: Is there a role in complex immunologic challenges? Hum Immunol. 2017 Feb;78(2):64-71. doi: 10.1016/j.humimm.2016.12.005. Epub 2016 Dec 18. Review. PubMed PMID: 27998802.
  7. Tieu R, Lakkis FG, Oberbarnscheidt MH. Getting Down and Dirty: Germ-Exposed Laboratory Mice as a Model of the Adult Human Immune System. Transplantation. 2016 Dec;100(12):2490-2491. PubMed PMID: 27861276; PubMed Central PMCID: PMC5120362.
  8. Alegre ML, Lakkis FG, Morelli AE. Antigen Presentation in Transplantation. Trends Immunol. 2016 Dec;37(12):831-843. doi: 10.1016/j.it.2016.09.003. Epub 2016 Oct 12. Review. PubMed PMID: 27743777; PubMed Central PMCID: PMC5135637.
  9. Zhuang Q, Liu Q, Divito SJ, Zeng Q, Yatim KM, Hughes AD, Rojas-Canales DM, Nakao A, Shufesky WJ, Williams AL, Humar R, Hoffman RA, Shlomchik WD, Oberbarnscheidt MH, Lakkis FG, Morelli AE. Graft-infiltrating host dendritic cells play a key role in organ transplant rejection. Nat Commun. 2016 Aug 24;7:12623. doi: 10.1038/ncomms12623. PubMed PMID: 27554168; PubMed Central PMCID: PMC4999515.
  10. Zhang Q, Dai H, Yatim KM, Abou-Daya K, Williams AL, Oberbarnscheidt MH, Camirand G, Rudd CE, Lakkis FG. CD8+ Effector T Cell Migration to Pancreatic Islet Grafts Is Dependent on Cognate Antigen Presentation by Donor Graft Cells. J Immunol. 2016 Aug 15;197(4):1471-6. doi: 10.4049/jimmunol.1600832. Epub 2016 Jun 29. PubMed PMID: 27357151; PubMed Central PMCID: PMC5023061.