Terence Dermody, MD

  • Vira I. Heinz Professor and Chair, Department of Pediatrics
  • Distinguished Professor of Pediatrics
  • Professor of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine
  • Physician-in-Chief and Scientific Director, UPMC Children’s Hospital of Pittsburgh

    Education & Training

  • Medical School – Columbia University College of Physicians & Surgeons – MD
  • Residency – Presbyterian Hospital of New York – Medicine
  • Fellowship – Harvard Medical School – Infectious Diseases
Research Grants

NIH Grants:  R01, K12

Research Summary

The work in Dr. Dermody's lab has encompassed several inter-related themes including the structural basis of viral attachment and cell entry; mechanisms of genome replication and packaging; patterns of cell signaling and gene expression occurring in response to viral infection; mechanisms of virus-induced apoptosis and its significance in the viral life cycle; and the role of viral receptor distribution and utilization in disease pathology. The lab also is studying links between reovirus and blockade of immunologic tolerance to new food antigens.

Representative Publications
  1. Kobayashi, T., Antar, A. A. R., Boehme, K. W., Danthi, P., Eby, E. A., Guglielmi, K. M., Holm, G. H., Johnson, E. M., Maginnis, M. S., Naik, S., Skelton, W. B., Wetzel, J. D., Wilson, G. J., Chappell, J. D., and T. S. Dermody. A plasmid-based reverse genetics system for animal double-stranded RNA viruses. Cell Host Microbe. 1:147-157, 2007. PMCID: PMC2034303
  2. Danthi, P., Pruijssers, A. J., Berger, A. K., Holm, G. H., Zinkel, S. S., and T. S. Dermody. Bid regulates the pathogenesis of neurotropic reovirus. PLoS Pathog. 6:e1000980, 2010. PMCID: PMC2895667
  3. Konopka-Anstadt, J. L., Mainou, B. A., Sutherland, D. M., Sekine, Y., Strittmatter, S. M., and T. S. Dermody. The Nogo receptor NgR1 mediates infection by mammalian reovirus. Cell Host Microbe. 15:681-691, 2014. PMCID: PMC4100558
  4. Bouziat, R., Hinterleitner, R., Brown, J. J., […], Dermody, T. S., and B. Jabri. Reovirus infection breaks tolerance to dietary antigens and promotes development of celiac disease. Science. 356:44-50, 2017. PMCID: PMC5506690
  5. Wu, A. G., Pruijssers, A. J., Brown, J. J., Stencel-Baerenwald, J. E., Sutherland, D. M., Iskarpatyoti, J. A., and T. S. Dermody. Age-dependent susceptibility to reovirus encephalitis in mice is influenced by maturation of the type-I interferon response. Pediatr. Res. 83:1057-1066, 2018. PMCID: PMC5959747
  6. Knowlton, J. J., Fernández de Castro, I., Ashbrook, A. W., Gestaut, D. R., Zamora, P. F., Bauer, J. A., Forrest, J. C., Frydman, J., Risco, C., and T. S. Dermody. The TRiC chaperonin controls reovirus replication through outer-capsid folding. Nat. Microbiol. 3:481-493, 2018. PMCID: PMC5874176