Gilles Clermont, MD

  • Director, Systems Medicine Program, CRISMA Center, Department of Critical Care Medicine
  • Co-Director, Clinical Research, Investigation, and Systems Modeling of Acute illness (CRISMA) Laboratory
  • Medical Director, Center for Inflammation and Regenerative Modeling
  • Professor of Critical Care Medicine, Industrial Engineering, & Mathematics
  • Associate Professor of Chemical Engineering
  • Associate Professor of Clinical and Translational Science

Education & Training

  • Medical School – McGill University – MD
  • Internship – Saint Mary’s Hospital, Montreal, Canada – Internal Medicine
  • Residency – University of Montreal, Montreal, Canada – Internal Medicine
  • Fellowship – University of Pittsburgh – Critical Care Medicine
  • Research Fellowship – University of Pittsburgh – Critical Care Medicine

Research Grants

NIH Grants:  R01, R13, R56, R21, R41

Research Summary

The exploration of the intersection of advanced quantitative methods and bedside care with the ultimate vision of leveraging mathematical, computational and engineering expertise to deliver improved personalized care to the critically ill.

Representative Publications

  1. Tasior M, Clermont G, Blanchard-Desce M, Jacquemin D, Gryko DT. Synthesis of Bis(arylethynyl)pyrrolo[3,2-b]pyrroles and Effect of Intramolecular Charge Transfer on Their Photophysical Behavior. Chemistry. 2018 Oct 1. doi: 10.1002/chem.201804325. [Epub ahead of print] PubMed PMID: 30276900.
  2. Murugan R, Balakumar V, Kerti SJ, Priyanka P, Chang CH, Clermont G, Bellomo R, Palevsky PM, Kellum JA. Net ultrafiltration intensity and mortality in critically ill patients with fluid overload. Crit Care. 2018 Sep 24;22(1):223. doi: 10.1186/s13054-018-2163-1. PubMed PMID: 30244678; PubMed Central PMCID: PMC6151928.
  3. Ramirez-Zuniga I, Rubin JE, Swigon D, Clermont G. Mathematical modeling of energy consumption in the acute inflammatory response. J Theor Biol. 2019 Jan 7;460:101-114. doi: 10.1016/j.jtbi.2018.08.033. Epub 2018 Aug 25. PubMed PMID: 30149010.
  4. Hravnak M, Pellathy T, Chen L, Dubrawski A, Wertz A, Clermont G, Pinsky MR. A call to alarms: Current state and future directions in the battle against alarm fatigue. J Electrocardiol. 2018 Nov - Dec;51(6S):S44-S48. doi: 10.1016/j.jelectrocard.2018.07.024. Epub 2018 Jul 29. Review. PubMed PMID: 30077422; PubMed Central PMCID: PMC6263784.
  5. Alves A, Attik N, Bayon Y, Royet E, Wirth C, Bourges X, Piat A, Dolmazon G, Clermont G, Boutrand JP, Grosgogeat B, Gritsch K. Devising tissue ingrowth metrics: a contribution to the computational characterization of engineered soft tissue healing. Biomed Mater. 2018 Mar 14;13(3):035010. doi: 10.1088/1748-605X/aaa9d4. PubMed PMID: 29359708.
  6. Peck Palmer OM, Rogers G, Yende S, Angus DC, Clermont G, Langston MA. Graph Theoretical Analysis of Genome-Scale Data: Examination of Gene Activation Occurring in the Setting of Community-Acquired Pneumonia. Shock. 2018 Jul;50(1):53-59. doi: 10.1097/SHK.0000000000001029. PubMed PMID: 29049138; PubMed Central PMCID: PMC6074040.
  7. Seymour CW, Gomez H, Chang CH, Clermont G, Kellum JA, Kennedy J, Yende S, Angus DC. Precision medicine for all? Challenges and opportunities for a precision medicine approach to critical illness. Crit Care. 2017 Oct 18;21(1):257. doi: 10.1186/s13054-017-1836-5. Review. PubMed PMID: 29047353; PubMed Central PMCID: PMC5648512.
  8. Keef E, Zhang LA, Swigon D, Urbano A, Ermentrout GB, Matuszewski M, Toapanta FR, Ross TM, Parker RS, Clermont G. Discrete Dynamical Modeling of Influenza Virus Infection Suggests Age-Dependent Differences in Immunity. J Virol. 2017 Nov 14;91(23). pii: e00395-17. doi: 10.1128/JVI.00395-17. Print 2017 Dec 1. PubMed PMID: 28904202; PubMed Central PMCID: PMC5686742.
  9. King AJ, Hochheiser H, Visweswaran S, Clermont G, Cooper GF. Eye-tracking for clinical decision support: A method to capture automatically what physicians are viewing in the EMR. AMIA Jt Summits Transl Sci Proc. 2017 Jul 26;2017:512-521. eCollection 2017. PubMed PMID: 28815151; PubMed Central PMCID: PMC5543363.
  10. Jolley SE, Hough CL, Clermont G, Hayden D, Hou S, Schoenfeld D, Smith NL, Thompson BT, Bernard GR, Angus DC; ARDS Network Investigators. Relationshipbetween Race and the Effect of Fluids on Long-term Mortality after Acute Respiratory Distress Syndrome. Secondary Analysis of the National Heart, Lung, and Blood Institute Fluid and Catheter Treatment Trial. Ann Am Thorac Soc. 2017 Sep;14(9):1443-1449. doi: 10.1513/AnnalsATS.201611-906OC. PubMed PMID: 28708421; PubMed Central PMCID: PMC5711400.
  11. Jin K, Murugan R, Sileanu FE, Foldes E, Priyanka P, Clermont G, Kellum JA. Intensive Monitoring of Urine Output Is Associated With Increased Detection of Acute Kidney Injury and Improved Outcomes. Chest. 2017 Nov;152(5):972-979. doi: 10.1016/j.chest.2017.05.011. Epub 2017 May 17. PubMed PMID: 28527880.
  12. Balakumar V, Murugan R, Sileanu FE, Palevsky P, Clermont G, Kellum JA. Both Positive and Negative Fluid Balance May Be Associated With Reduced Long-Term Survival in the Critically Ill. Crit Care Med. 2017 Aug;45(8):e749-e757. doi:10.1097/CCM.0000000000002372. PubMed PMID: 28437375; PubMed Central PMCID: PMC5511076.
  13. Bose EL, Clermont G, Chen L, Dubrawski AW, Ren D, Hoffman LA, Pinsky MR, Hravnak M. Cardiorespiratory instability in monitored step-down unit patients: using cluster analysis to identify patterns of change. J Clin Monit Comput. 2018 Feb;32(1):117-126. doi: 10.1007/s10877-017-0001-7. Epub 2017 Feb 22. PubMed PMID: 28229353; PubMed Central PMCID: PMC5957274.
  14. Bose E, Chen L, Clermont G, Dubrawski A, Pinsky MR, Ren D, Hoffman LA, Hravnak M. Risk for Cardiorespiratory Instability Following Transfer to a Monitored Step-Down Unit. Respir Care. 2017 Apr;62(4):415-422. doi: 10.4187/respcare.05001. Epub 2017 Jan 24. PubMed PMID: 28119497.
  15. Tran C, Berqouch N, Dhimane H, Clermont G, Blanchard-Desce M, Ogden D, Dalko PI. Quinoline-Derived Two-Photon Sensitive Quadrupolar Probes. Chemistry. 2017 Feb 3;23(8):1860-1868. doi: 10.1002/chem.201604500. Epub 2017 Jan 3. PubMed PMID: 28052481.
  16. Chen L, Ogundele O, Clermont G, Hravnak M, Pinsky MR, Dubrawski AW. Dynamic and Personalized Risk Forecast in Step-Down Units. Implications for Monitoring Paradigms. Ann Am Thorac Soc. 2017 Mar;14(3):384-391. doi: 10.1513/AnnalsATS.201611-905OC. PubMed PMID: 28033032; PubMed Central PMCID: PMC5427723.
  17. Hravnak M, Chen L, Dubrawski A, Bose E, Clermont G, Pinsky MR. Real alerts and artifact classification in archived multi-signal vital sign monitoring data: implications for mining big data. J Clin Monit Comput. 2016 Dec;30(6):875-888. Epub 2015 Oct 5. PubMed PMID: 26438655; PubMed Central PMCID: PMC4821824.
  18. Hauskrecht M, Batal I, Hong C, Nguyen Q, Cooper GF, Visweswaran S, Clermont G. Outlier-based detection of unusual patient-management actions: An ICU study. J Biomed Inform. 2016 Dec;64:211-221. doi: 10.1016/j.jbi.2016.10.002. Epub 2016 Oct 5. PubMed PMID: 27720983; PubMed Central PMCID: PMC5207478.
  19. Sen A, Keener CM, Sileanu FE, Foldes E, Clermont G, Murugan R, Kellum JA. Chloride Content of Fluids Used for Large-Volume Resuscitation Is Associated With Reduced Survival. Crit Care Med. 2017 Feb;45(2):e146-e153. doi: 10.1097/CCM.0000000000002063. PubMed PMID: 27635770; PubMed Central PMCID: PMC6121711.
  20. Griesbeck S, Zhang Z, Gutmann M, Lühmann T, Edkins RM, Clermont G, Lazar AN, Haehnel M, Edkins K, Eichhorn A, Blanchard-Desce M, Meinel L, Marder TB. Water-Soluble Triarylborane Chromophores for One- and Two-Photon Excited Fluorescence Imaging of Mitochondria in Cells. Chemistry. 2016 Oct 4;22(41):14701-6. doi: 10.1002/chem.201602639. Epub 2016 Sep 15. PubMed PMID: 27627995.