David A. Geller, MD, FACS

  • Richard L. Simmons Professor of Surgery
  • Chief, Division of Hepatobiliary and Pancreatic Surgery
  • Director, UPMC Liver Cancer Center

Education & Training

  • Medical School – Northwestern University – MD
  • Residency – University of Pittsburgh School of Medicine – General Surgery
  • Fellowship – University of Pittsburgh School of Medicine – Surgery Research
  • Fellowship – UPMC Starzl Transplantation Institute – Transplantation Surgery

Research Grants

R01, R42, R01

Research Summary

The Geller lab focuses on HCC cancer signaling pathways as well as liver transplant ischemia/reperfusion injury. In addition, there is a strong emphasis on translational research with gene therapy trials in liver cancer.

Representative Publications

  1. Yang MQ, Du Q, Goswami J, Varley PR, Chen B, Wang RH, Morelli AE, Stolz DB, Billiar TR, Li J, Geller DA. Interferon regulatory factor 1-Rab27a regulated extracellular vesicles promote liver ischemia/reperfusion injury. Hepatology. 2018; 67:1056-1070.  
  2. Yang MQ, Du Q, Varley PR, Goswami J, Liang Z, Wang R, Li H, Stolz DB, Geller DA. Interferon regulatory factor 1 priming of tumor-derived exosomes enhances the antitumor immune response. Br J Cancer. 2018; 118:62-71.  
  3. Ono Y, Perez-Gutierrez A, Nakao T, Dai H, Camirand G, Yoshida O, Yokota S, Stolz DB, Ross MA, Morelli AE, Geller DA, Thomson AW. Graft-infiltrating PD-L1hi cross-dressed dendritic cells regulate anti-donor T cell responses in mouse liver transplant tolerance. Hepatology. 2018; 67:1499-1515.  
  4. Nakao T, Ono Y, Dai H, Nakano R, Perez-Gutierrez A, Camirand G, Huang H, Geller DA, Thomson AW. DAP12/TREM2 Expression by Mouse and Human Liver DC: Functional Implications and Regulation of Liver Ischemia-Reperfusion Injury. Hepatology. 2018 Oct 29. [Epub ahead of print]  
  5. Wang R, Li Y, Tsung A, Huang H, Du Q, Yang M, Deng M, Xiong S, Wang X, Zhang L, Geller DA, Cheng B, Billiar TR.  iNOS promotes CD24+CD133+ liver cancer stem cell phenotype through a TACE/ADAM17-dependent Notch signaling pathway. Proc Natl Acad Sci U S A. 2018; 115: E10127-E10136.  
  6. Wan P, Chi X, Du Q, Luo J, Cui X, Dong K, Bing Y, Heres C, Geller DA. miR-383 promotes cholangiocarcinoma cell proliferation, migration, and invasion through targeting IRF1.  J Cellular Biochem. 2018; 119:9720-9729.  
  7. Buijs N, Oosterink JE, Jessup M, Schierbeek, H, Soltz DB, Houdijk AP, Geller DA, van Leeuwe PA. A new key player in VEGF-dependent angiogenesis in human hepatocellular carcinoma: dimethylarginine dimethylaminohydrolase 1. Angiogenesis, 2017; 20:557-565.