Ora Weisz, PhD

  • Professor of Medicine and of Cell Biology, and Clinical and Translational Science
  • Vice Chair for Faculty Development, Department of Medicine
  • Associate Dean for Faculty Development, School of Medicine
  • Assistant Vice Chancellor for Faculty Excellence, Health Sciences

Education & Training

  • Graduate School – Johns Hopkins University – PhD – Biochemistry and Cellular & Molecular Biology

Research Grants

NIH Grants:  R01

Research Summary

Our laboratory focuses broadly on understanding how membrane traffic in proximal tubule cells responds to physiologic cues to maintain kidney function. We are unraveling the mechanisms by which newly synthesized proteins are sorted and delivered to the appropriate plasma membrane domains of differentiated kidney cells. We have been generating new in vitro and ex vivo systems, including disease models in cells and mice, to determine how proximal tubule cells in the kidney alter their endocytic and ion transport capacity in response to changes in tubular flow and the accompanying fluid shear stress. These studies have direct implications for the understanding and treatment of genetic and other disorders that result in tubular proteinuria and eventually lead to kidney failure, including Lowe syndrome, Dent disease, and sickle cell disease.

Representative Publications

 

  1. Weisz OA, Baty CJ. Lemmings into the sea or back across the bridge? The fate of albumin in nephrotic syndrome. Kidney Int. 2018 Feb;93(2):296-298. doi: 10.1016/j.kint.2017.08.037. PubMed PMID: 29389392.
  2. Long KR, Shipman KE, Rbaibi Y, Menshikova EV, Ritov VB, Eshbach ML, Jiang Y, Jackson EK, Baty CJ, Weisz OA. Proximal tubule apical endocytosis is modulated by fluid shear stress via an mTOR-dependent pathway. Mol Biol Cell. 2017 Sep 15;28(19):2508-2517. doi: 10.1091/mbc.E17-04-0211. Epub 2017 Jul 18. PubMed PMID: 28720662; PubMed Central PMCID: PMC5597323.
  3. Eshbach ML, Sethi R, Avula R, Lamb J, Hollingshead DJ, Finegold DN, Locker JD, Chandran UR, Weisz OA. The transcriptome of the Didelphis virginiana opossum kidney OK proximal tubule cell line. Am J Physiol Renal Physiol. 2017 Sep 1;313(3):F585-F595. doi: 10.1152/ajprenal.00228.2017. Epub 2017 Jun 14. PubMed PMID: 28615248; PubMed Central PMCID: PMC5625107.
  4. Eshbach ML, Kaur A, Rbaibi Y, Tejero J, Weisz OA. Hemoglobin inhibits albumin uptake by proximal tubule cells: implications for sickle cell disease. Am J Physiol Cell Physiol. 2017 Jun 1;312(6):C733-C740. doi: 10.1152/ajpcell.00021.2017. Epub 2017 Mar 29. PubMed PMID: 28356267; PubMed Central PMCID: PMC5494590.
  5. Eshbach ML, Weisz OA. Receptor-Mediated Endocytosis in the Proximal Tubule. Annu Rev Physiol. 2017 Feb 10;79:425-448. doi: 10.1146/annurev-physiol-022516-034234. Epub 2016 Oct 28. Review. PubMed PMID: 27813828; PubMed Central PMCID: PMC5512543.
  6. Pereira EM, Labilloy A, Eshbach ML, Roy A, Subramanya AR, Monte S, Labilloy G, Weisz OA. Characterization and phosphoproteomic analysis of a human immortalized podocyte model of Fabry disease generated using CRISPR/Cas9 technology. Am J Physiol Renal Physiol. 2016 Nov 1;311(5):F1015-F1024. doi: 10.1152/ajprenal.00283.2016. Epub 2016 Sep 28. PubMed PMID: 27681560; PubMed Central PMCID: PMC5130460 
  7. Raghavan V, Rbaibi Y, Pastor-Soler NM, Carattino MD, Weisz OA. Shear stress-dependent regulation of apical endocytosis in renal proximal tubule cells mediated by primary cilia. Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8506-11. doi: 10.1073/pnas.1402195111. Epub 2014 May 27. Erratum in: Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):E1587. PubMed PMID: 24912170; PubMed Central PMCID: PMC4060694. 
  8. Bhattacharyya S, Jean-Alphonse FG, Raghavan V, McGarvey JC, Rbaibi Y, Vilardaga JP, Carattino MD, Weisz OA. Cdc42 activation couples fluid shear stress to apical endocytosis in proximal tubule cells. Physiol Rep. 2017 Oct;5(19). pii: e13460. doi: 10.14814/phy2.13460. Epub 2017 Oct 16. PubMed PMID: 29038362; PubMed Central PMCID: PMC5641940.