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Mark Shlomchik, MD, PhD

  • Professor and Chair, Immunology

    Education & Training

  • Graduate School – University of Pennsylvania – PhD – Immunology
  • Medical School – University of Pennsylvania – MD
  • Residency – Hospital of University of Pennsylvania – Pathology
  • Post-Doctoral – Fox Chase Cancer Center - Immunology
Research Grants

NIH Grants:  R01, P01, R13, R56

Research Summary

Dr. Shlomchik’s lab is interested in systemic autoimmune diseases, long-lived B cell immunity, and in immunopathogenesis. They are using transgenic and knockout mouse models to address the questions of how autoreactive B cells arise and what is the role(s) that these cells play in mediating autoimmune disease. They have also used genetic approaches to test the roles of CD11c+ and other myeloid cells in promoting murine lupus and autoreactive B cell activation. Dr. Shlomchik continues to work regulatory role of TLR9 and stimulatory role of TLR7 in lupus and to define how TLRs function in a tissue-specific fashion, including recently defining the role of MyD88; this recently resulted in an NIH MERIT award. Regarding B cell immunity, the Shlomchik lab has made recent insights into the mechanisms of cellular selection and differentiation in the germinal center, a site of rapid proliferation, mutation, and differentiation into memory cells. The Shlomchik group has identified novel subsets of memory B cells in mice and are studying their origins and function, recently showing that the germinal center shifts its output from memory B cells to plasma cells as it matures with time. Dr. Shlomchik is the PI of a T32 on Autoimmunity and Immunopathology. He has trained over 35 students and fellows, most of whom remain in science and several of whom have independent faculty positions. His position as a physician-scientist conducting disease-related basic research has enabled him to provide a combination of scientific and career advice and mentoring that has in turn made his lab an attractive destination for trainees with similar interests and background.   

Representative Publications
  1. Luo W, Weisel F, Shlomchik  MJ. B Cell receptor and CD40 signaling Are rewired for synergistic induction of the c-Myc transcription factor in germinal center B cells. Immunity. 2018;48:313-326. PMCID: PMC5821563.
  2. Tilstra JS, Avery L, Menk AV, Gordon RA, Smita S, Kane LP, Chikina M, Delgoffe GM, Shlomchik MJ. Kidney-infiltrating T cells in murine lupus nephritis are metabolically and functionally exhausted. J Clin Inv. 2018. In press.
  3. Giles JR, Turqueti-Neves A, Marshak-Rothstein A, Shlomchik MJ. Autoreactive helper T cells alleviate the need for intrinsic TLR signaling in autoreactive B cell activation. JCI Insight. 2017;2(4):e90870. doi:10.1172/jci.insight.90870. PMCID: PMC5313065.
  4. Gordon RA, Herter JM, Rosetti F, Campbell AM, Nishi H, Kashgarian M, Bastacky SI, Marinov A, Nickerson KM, Mayadas TN, Shlomchik MJ. Lupus and Proliferative Nephritis are PAD4 Independent in Murine Models. JCI Insight. 2017;2(10):e92926. doi:10.1172/jci.insight. 92926. PMCID: PMC5436537.
  5. Weisel FW, Chikina M, Shlomchik MJ. A temporal switch in the germinal center determines differential output of memory B and plasma cells. Immunity. 2016;44: 116-130. PMCID: PMC4724390.
  6. Ols ML, Cullen JL, Turqueti-Neves A, Giles J, Shlomchik MJ. Dendritic cells regulate extrafollicular autoreactive B cells via T cells expressing Fas and Fas ligand. Immunity. 2016; 45:1052-65. PMCID: PMC5112117.