Richard Steinman, MD, PhD

  • Associate Dean, Director Medical Scientist Training Program
  • Director, Physician Scientist Incubator Program
  • Director, Physician Scientist Training Program
  • Associate Professor of Medicine and Pharmacology

Education & Training

  • Graduate School – University of Pennsylvania – PhD – Biochemistry
  • Medical School – University of Pennsylvania - MD

Research Grants

NIH Grants:  NIH T32 Commonwealth of Pennsylvania CURE

Research Summary

Dr. Steinman has interrogated the function and regulation of cdk inhibitors during quiescence and differentiation. His recent research focuses on dissection of the tumor microenvironment, including the development of a tool to enable topographically-restricted genetic manipulation of cells adjacent to cancer. Current questions under investigation include the contribution of fibrosis to metastatic growth and stromal factors that impact cancer dormancy and recurrence.

Representative Publications

  1. Huang J, Woods P, Normolle D, Goff JP, Benos PV, Stehle CJ, Steinman RA. Downregulation of estrogen receptor and modulation of growth of breast cancer cell lines mediated by paracrine stromal cell signals. Breast Cancer Res Treat. 2017 Jan;161(2):229-243. doi: 10.1007/s10549-016-4052-0. Epub 2016 Nov 16. PubMed PMID: 27853906; PubMed Central PMCID: PMC5556382.
  2. Steinman RA, Robinson AR, Feghali-Bostwick CA. Antifibrotic effects of roscovitine in normal and scleroderma fibroblasts. PLoS One. 2012;7(11):e48560. doi: 10.1371/journal.pone.0048560. Epub 2012 Nov 20. PubMed PMID: 23185265; PubMed Central PMCID: PMC3502367.
  3. Steinman RA, Yang Q, Gasparetto M, Robinson LJ, Liu X, Lenzner DE, Hou J, Smith C, Wang Q. Deletion of the RNA-editing enzyme ADAR1 causes regression of established chronic myelogenous leukemia in mice. Int J Cancer. 2013 Apr 15;132(8):1741-50. doi: 10.1002/ijc.27851. Epub 2012 Oct 17. PubMed PMID: 22987615; PubMed Central PMCID: PMC3565035
  4. Steinman R. Cancer therapeutics: time to swim downstream? Oncologist. 2011;16(10):1479-80. doi: 10.1634/theoncologist.2011-0241. PubMed PMID: 22016496; PubMed Central PMCID: PMC3228067.
  5. Yasuoka H, Hsu E, Ruiz XD, Steinman RA, Choi AM, Feghali-Bostwick CA. The fibrotic phenotype induced by IGFBP-5 is regulated by MAPK activation and egr-1-dependent and -independent mechanisms. Am J Pathol. 2009 Aug;175(2):605-15. doi: 10.2353/ajpath.2009.080991. Epub 2009 Jul 23. PubMed PMID: 19628764; PubMed Central PMCID: PMC2716960.
  6. Nichols M, Steinman RA. A recombinase-based palindrome generator capable of producing randomized shRNA libraries. J Biotechnol. 2009 Aug 20;143(2):79-84. doi: 10.1016/j.jbiotec.2009.06.010. Epub 2009 Jun 17. PubMed PMID: 19539675.
  7. Steinman RA. mRNA stability control: a clandestine force in normal and malignant hematopoiesis. Leukemia. 2007 Jun;21(6):1158-71. Epub 2007 Mar 29. Review. PubMed PMID: 17392821.
  8. Duensing A, Ghanem L, Steinman RA, Liu Y, Duensing S. p21(Waf1/Cip1) deficiency stimulates centriole overduplication. Cell Cycle. 2006 Dec;5(24):2899-902. Epub 2006 Dec 15. PubMed PMID: 17172866; PubMed Central PMCID: PMC2275058.