Sohail Husain, MD

  • Director of the Exocrine Pancreas Center at the Children’s Hospital of Pittsburgh of UPMC
  • Associate Director, Pediatric Gastroenterology Fellowship Program, University of Pittsburgh
  • Professor, Pediatrics

Education & Training

  • Medical School – Tufts University School of Medicine – MD
  • Residency – New York University Medical Center – Pediatrics
  • Fellowship – Yale University – Pediatric Gastroenterology

Research Grants

NIH Grants:  R01

Research Summary

Dr. Husain studies the pathogenesis of pancreatic injury. His laboratory has found that abnormally elevated calcium signals are associated with pathological intra-acinar protease activation, which serves as a critical early step in the development of pancreatitis. He uses mouse models of pancreatitis to provide a detailed elucidation of the calcium signaling network and the role of calcineurin as a means to identify specific targets for new therapies. His work also has shown that pancreatic injury leads to a specific change in epigenetic regulation and, in particular, histone deacetylases appear to be excellent therapeutic targets to ameliorate pancreatitis. Another area of research in Dr. Husain’s lab is to probe the mechanisms underlying drug-induced pancreatitis. Dr. Husain has served as a primary mentor for numerous post-doctoral associates, fellows, and medical and undergraduate students.

Representative Publications

  1. Uc A, Perito ER, Pohl JF, Shah U, Abu-El-Haija M, Barth B, Bellin MD, Ellery KM, Fishman DS, Gariepy CE, Giefer MJ, Gonska T, Heyman MB, Himes RW, Husain SZ, Maqbool A, Mascarenhas MR, McFerron BA, Morinville VD, Lin TK, Liu QY, Nathan JD, Rhee SJ, Ooi CY, Sellers ZM, Schwarzenberg SJ, Serrano J, Troendle DM, Werlin SL, Wilschanski M, Zheng Y, Yuan Y, Lowe ME; Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC). International Study Group of Pediatric Pancreatitis: In Search for a CuRE Cohort Study: Design and Rationale for INSPPIRE 2 From the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer. Pancreas. 2018 Nov/Dec;47(10):1222-1228. doi: 10.1097/MPA.0000000000001172. PubMed PMID: 30325861; PubMed Central PMCID: PMC6195325.
  2. Forsmark CE, Andersen DK, Farrar JT, Golden M, Habtezion A, Husain SZ, Li L, Mayerle J, Pandol SJ, Uc A, Zhu Z, Yadav D. Accelerating the Drug Delivery Pipeline for Acute and Chronic Pancreatitis: Summary of the Working Group on Drug Development and Trials in Chronic Pancreatitis at the National Institute of Diabetes and Digestive and Kidney Diseases Workshop. Pancreas. 2018 Nov/Dec;47(10):1200-1207. doi: 10.1097/MPA.0000000000001174. PubMed PMID: 30325858; PubMed Central PMCID: PMC6196743.
  3. Sweeny KF, Lin TK, Nathan JD, Denson LA, Husain SZ, Hornung L, Thompson T, Abu-El-Haija M. Rapid Progression of Acute Pancreatitis to Acute Recurrent Pancreatitis in Children. J Pediatr Gastroenterol Nutr. 2018 Sep 18. doi: 10.1097/MPG.0000000000002145. [Epub ahead of print] PubMed PMID: 30234758.
  4. Uc A, Zimmerman MB, Wilschanski M, Werlin SL, Troendle D, Shah U, Schwarzenberg SJ, Rhee S, Pohl JF, Perito ER, Palermo JJ, Ooi CY, Liu Q, Lin TK, Morinville VD, McFerron BA, Husain SZ, Himes R, Heyman MB, Gonska T, Giefer MJ, Gariepy CE, Freedman SD, Fishman DS, Bellin MD, Barth B, Abu-El-Haija M, Lowe ME. Impact of Obesity on Pediatric Acute Recurrent and Chronic Pancreatitis. Pancreas. 2018 Sep;47(8):967-973. doi: 10.1097/MPA.0000000000001120. PubMed PMID: 30059474; PubMed Central PMCID: PMC6095802.
  5. Wen L, Javed TA, Yimlamai D, Mukherjee A, Xiao X, Husain SZ. Transient High Pressure in Pancreatic Ducts Promotes Inflammation and Alters Tight Junctions via Calcineurin Signaling in Mice. Gastroenterology. 2018 Oct;155(4):1250-1263.e5. doi: 10.1053/j.gastro.2018.06.036. Epub 2018 Jun 19. PubMed PMID: 29928898; PubMed Central PMCID: PMC6174093.
  6. Sellers ZM, Abu-El-Haija M, Husain SZ, Morinville V. New Management Guidelines for Both Children and Adults With Acute Pancreatitis. Gastroenterology. 2018 Jul;155(1):234-235. doi: 10.1053/j.gastro.2018.03.068. Epub 2018 Jun 8. PubMed PMID: 29890113.
  7. Lin TK, Abu-El-Haija M, Nathan JD, Palermo JP, Barth B, Bellin M, Fishman DS, Freedman SD, Gariepy CE, Giefer MJ, Gonska T, Heyman MB, Himes R, Husain SZ, Liu Q, Maqbool A, Mascarenhas M, McFerron B, Morinville VD, Ooi CY, Perito E, Pohl JF, Rhee S, Schwarzenberg SJ, Shah U, Troendle D, Werlin SL, Wilschanski M, Zimmerman MB, Lowe ME, Uc A. Pancreas Divisum in Pediatric Acute Recurrent and Chronic Pancreatitis: Report From INSPPIRE. J Clin Gastroenterol. 2018 Jun 2. doi: 10.1097/MCG.0000000000001063. [Epub ahead of print] PubMed PMID: 29864067; PubMed Central PMCID: PMC6275137.
  8. Scheers I, Palermo JJ, Freedman S, Wilschanski M, Shah U, Abu-El-Haija M, Barth B, Fishman DS, Gariepy C, Giefer MJ, Heyman MB, Himes RW, Husain SZ, Lin TK, Liu Q, Lowe M, Mascarenhas M, Morinville V, Ooi CY, Perito ER, Piccoli DA, Pohl JF, Schwarzenberg SJ, Troendle D, Werlin S, Zimmerman B, Uc A, Gonska T. Recommendations for Diagnosis and Management of Autoimmune Pancreatitis in Childhood: Consensus From INSPPIRE. J Pediatr Gastroenterol Nutr. 2018 Aug;67(2):232-236. doi: 10.1097/MPG.0000000000002028. PubMed PMID: 29746340; PubMed Central PMCID: PMC6059991.
  9. Boggs K, Wang T, Orabi AI, Mukherjee A, Eisses JF, Sun T, Wen L, Javed TA, Esni F, Chen W, Husain SZ. Pancreatic gene expression during recovery after pancreatitis reveals unique transcriptome profiles. Sci Rep. 2018 Jan 23;8(1):1406. doi: 10.1038/s41598-018-19392-0. PubMed PMID: 29362419; PubMed Central PMCID: PMC5780441.
  10. Abu-El-Haija M, Kumar S, Quiros JA, Balakrishnan K, Barth B, Bitton S, Eisses JF, Foglio EJ, Fox V, Francis D, Freeman AJ, Gonska T, Grover AS, Husain SZ, Kumar R, Lapsia S, Lin T, Liu QY, Maqbool A, Sellers ZM, Szabo F, Uc A, Werlin SL, Morinville VD. Management of Acute Pancreatitis in the Pediatric Population: A Clinical Report From the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition Pancreas Committee. J Pediatr Gastroenterol Nutr. 2018 Jan;66(1):159-176. doi: 10.1097/MPG.0000000000001715. PubMed PMID: 29280782; PubMed Central PMCID: PMC5755713.