Site Chief of Vascular Services, Magee-Womens Hospital of UPMC
Research Focus:

Dr. Sachdev-Ost’s research has focused on the role of danger signaling, toll-like receptors (TLRs) and autophagy in regulating recovery from ischemic muscle injury.  This work has potential implications in patients with peripheral vascular disease. Recently, she has also been studying growth and functional characteristics of muscle satellite cells that are harvested from patients with PAD, to determine whether they can be used in therapeutic applications. Finally, she is also studying the role of inflammation in patients with chronic venous insufficiency.

Executive Director, Magee-Womens Research Institute
Research Focus:

Placental biology, seeking to decipher the molecular mechanisms underlying placental dysfunction, which impacts pregnancy and impedes fetal growth with devastating consequences to the mother and newborn

Director of Graduate Education for Surgery Research
Research Focus:
  • The role of the inflammasome and caspase-1 in trauma and hemorrhage
  • The role of the inflammasome and caspase-1 in sepsis
  • Inflammasome activation and metabolic control in the liver and during surgery
Director, Nitric Oxide Metabolomics Core Facility
Research Focus:
  • Redox Biology
  • Signal Transduction
  • Translational Biomarkers
  • Biochemical and Molecular Pharmacology
Professor and Chair, Immunology
Research Focus:

B cell immune response and how the immune system is activated in systemic autoimmunity leading to pathogenesis

Professor and Gerald E. McGinnis Chair in Bioengineering
Research Focus:

Myocardial proteins and whole heart mechano-energetic function; Vascular stiffness and cardiovascular function; Large-scale mathematical models of biological systems

Chair, Department of Microbiology and Molecular Genetics
Research Focus:

Role of protein-tyrosine kinase signaling pathways in cancer, HIV/AIDS, and embryonic stem cell differentiation. Our research program is interdisciplinary, integrating techniques of chemical genetics, biochemistry, molecular biology and biophysics to gain insight into the role of kinase signaling pathways in ES cell fate, cancer and AIDS

Tenured Professor and Chair of Physical Medicine & Rehabilitation
Research Focus:

Active research program investigating the role of mechanical forces in disc degeneration

Associate Dean, Director Medical Scientist Training Program
Research Focus:

Cancer Pharmacology

UPMC Professor of Psychiatric Neuroscience and Professor of Neurology
Research Focus:

Neurobiological mechanisms underlying the occurrence of psychotic symptoms, delusions and hallucinations