Philana Ling Lin, MD, MSc

  • Fellowship Director, Pediatric Infectious Diseases Program
  • Associate Professor, Pediatrics

Education & Training

  • Graduate School – University of Pittsburgh - MSc
  • Medical School – Northeastern Ohio University College of Medicine – MD
  • Residency – University of Chicago – Pediatrics
  • Fellowship – Children’s Hospital of Pittsburgh UPMC – Pediatric Infectious Disease

Research Grants

NIH Grants: R21, R01, R56

Research Summary

Dr. Lin studies various aspects of the host protective immune responses to Mycobacterium tuberculosis (Mtb), the bacilli that cause tuberculosis (TB). Tuberculosis is now the most common infectious cause of death worldwide and efforts to develop an effective vaccine and improve treatment regimens are ongoing. Using an animal model of human Mtb, Dr. Lin’s research is focused on the immunologic mechanisms that are responsible to control the infection both in the healthy host and in those with HIV infection (who are at greatest risk of severe disease).  Using large-scale in-vivo imaging and modern molecular genetic techniques, her lab is able to better understand the pathogenesis of disease in conjunction with the host immune response. Identifying biomarkers of disease severity, examining the impact of innate and early adaptive response in the airway and understanding the interaction between both HIV and Mtb during HIV-TB co-infected patients are also major interests in the lab. Her laboratory offers an ideal environment for training faculty in Immunology, Infectious Diseases, and Pulmonology.

Representative Publications

  1. Diedrich C.R., Gideon H.P, Rutledge T., Baranowski, T.M., Maeillo P., Myers A.J., Lin P.L. CD4CD8 Double Positive T cell response during M. tuberculosis infection in cynomolgus macaques. Journal of Primatology. 2019;48:82-89.
  2. Gideon HP, Skinner JA, Baldwin N, Flynn JL, Lin PL. Early whole blood transcriptional signatures are associated with severity of lung inflammation in cynomolgus macaques with Mycobacterium tuberculosis infection. J Immunol. 2016;197(12):4817-4828. Pubmed PMID: 27837110;  PMCID: PMC5289749
  3. Ganchua SKC, Cadena AM, Maiello P, Gideon HP, Myers AJ, Junecko BF, Klein EC, Lin PL, Mattila JT, Flynn JL. Lymph nodes are sites of prolonged bacterial persistence during Mycobacterium tuberculosis infection in macaques. PLoS Pathog.2018 Nov 1;14(11):e1007337. doi: 10.1371/journal.ppat.1007337. eCollection 2018Nov. PubMed PMID: 30383808; PubMed Central PMCID: PMC6211753.
  4. Lin PL, Flynn JL. The End of the Binary Era: Revisiting the Spectrum of tuberculosis. J Immunol. 2018 Nov 1;201(9):2541-2548. doi:10.4049/jimmunol.1800993. Review. PubMed PMID: 30348659; PubMed Central PMCID:PMC6217958.
  5. Gregg RW, Maiello P, Borish HJ, Coleman MT, Reed DS, White AG, Flynn JL, Lin PL. Spatial and temporal evolution of lung granulomas in a cynomolgus macaque model of Mycobacterium tuberculosis infection. Radiology of Infectious Diseases. 2018;5:110-117.
  6. Cadena AM, Hopkins FF, Maiello P, Carey AF, Wong EA, Martin CJ, Gideon HP, DiFazio RM, Andersen P, Lin PL, Fortune SM, Flynn JL. Concurrent infection with mycobacterium tuberculosis confers robust protection against secondary infection in macaques. PLoS Pathog. 2018 Oct 12;14(10):e1007305. doi:10.1371/journal.ppat.1007305. eCollection 2018 Oct. PubMed PMID: 30312351; PubMed Central PMCID: PMC6200282.
  7. Cadena AM, Ma Y, Ding T, Bryant M, Maiello P, Geber A, Lin PL, Flynn JL, Ghedin E. Profiling the airway in the macaque model of tuberculosis reveals variable microbial dysbiosis and alteration of community structure. Microbiome. 2018 Oct 9;6(1):180. doi: 10.1186/s40168-018-0560-y. PubMed PMID: 30301469; PubMed Central PMCID: PMC6178261.
  8. Thompson EG, Shankar S, Gideon HP, Braun J, Valvo J, Skinner JA, Aderem A, Flynn JL, Lin PL, Zak DE. Prospective Discrimination of Controllers From Progressors Early After Low-Dose Mycobacterium tuberculosis Infection of Cynomolgus Macaques using Blood RNA Signatures. J Infect Dis. 2018 Mar 28;217(8):1318-1322. doi: 10.1093/infdis/jiy006. PubMed PMID: 29325117; PubMed Central PMCID: PMC6018950.