Kevin P Mollen, MD

  • Samuel P. Harbison Assistant Professor of Surgery
  • Surgical Director, Inflammatory Bowel Disease Center, Children’s Hospital of Pittsburgh of UPMC
  • Scholar, R.K. Mellon Institute for Pediatric Research

Education & Training

  • Medical School – University of Buffalo School of Medicine – MD
  • Residency – University of Pittsburgh – General Surgery
  • Fellowship – Children’s Hospital of Pittsburgh of UPMC – Pediatric Surgery

Research Grants

NIH Grants:  K08, R03

Representative Publications

  1. Steen EH, Moles CM, Goldstein AM, Morowotz MJ, Gosain A, Mollen KP, Hackam D, Keswani SG. The Pediatric Surgeon-Scientist: Succeeding in Today’s Academic Environment. J Surg Res. 2019 Jul 19;244:502-508. PMID: 31330294  
  2. Yeh A, Conners EM, Ramos-Jimenez RG, Firek B, Novak EA, Rogers MB, Cheek R, Ozolek J, Mollen KP, Morowitz MJ. Plant-based Enteral Nutrition Modifies the Gut Microbiota and Improves Outcomes in Murine Models of Colitis. Cell Mol Gastroenterol Hepatol. 2019;7(4):872-874. PMID: 30716421  
  3. Haberman Y, Karns R, Dexheimer PJ, Schirmer M, Somekh J, Jurickova I, Braun T, Novak E, Bauman L, Collins MH, Mo A, Rosen MJ, Bonkowski E, Gotman N, Marquis A, Nistel M, Rufo PA, Baker SS, Sauer CG, Markowitz J, Pfefferkorn MD, Rosh JR, Boyle BM, Mack DR, Baldassano RN, Shah S, Leleiko NS, Heyman MB, Grifiths AM, Patel AS, Noe JD, Aronow BJ, Kugathasan S, Walters TD, Gibson G, Thomas SD, Mollen K, Shen-Orr S, Huttenhower C, Xavier RJ, Hyams JS, Denson LA. Ulcerative colitis mucosal transcriptomes reveal michondriopathy and personalized mechanisms underlying disease severity and treatment response. Nat Commun. 2019 Jan 3;10(1):38. PMID: 30604764  
  4. Cunningham KE, Novak EA, Vincent G, Siow VS, Griffith BD, Ranganathan S, Rosengart MR, Piganelli JD, and Mollen KP. Calcium/calmodulin-dependent protein kinase IV (CaMKIV) activation contributes to the pathogenesis of experimental colitis via inhibition of intestinal epithelial cell proliferation. FASEB J. 2019 Jan;33(1): 1330-1346. PMID: 30113881  
  5. Coudriet GM, Delmastro-Greenwood MM, Previte DM, Marré ML, O’Connor EC, Novak EA, Vincent G, Mollen KP, Lee S, Dong HH, Piganelli JD.  Treatment with a Catalytic Superoxide Dismutase (SOD) Mimetic Improves Liver Steatosis, Insulin Sensitivity, and Inflammation in Obesity-Induced Type 2 Diabetes.  Antioxidants (Basel).  2017 Nov 1;6(4). pii: E85. doi: 10.3390/antiox6040085. PMID 29104232  
  6. Previte DM, O’Connor EC, Novak EA, Martins CP, Mollen KP, Piganelli JD. Reactive oxygen species are required for driving efficient and sustained aerobic glycolysis during CD4+ T cell activation. PLoS One. 2017 Apr 20;12(4):e0175549. PMID: 2846686  
  7. Mazuski JE, Tessier JM, May AK, Sawyer RG, Nadler EP, Rosengart MR, Chang PK, O’Neill PJ, Mollen KP, Huston JM, Diaz JJ Jr, Prince JM. The Surgical Infection Society revised guidelines on the management of intra-abdominal infection. Surg Infect. 2017 Jan;18(1):1-76. PMID: 28085573  
  8. Siow VS, Bhatt R, Mollen KP. Management of acute severe ulcerative colitis in children.  Semin Pediatr Surg. 2017 Dec;26(6):367-372. PMID 29126505  
  9. Cunningham KE, Vincent G, Sodhi CP, Novak EA, Ranganathan S, Egan CE, Stolz DB, Rogers MB, Firek B, Morowitz MJ, Gittes GK, Zuckerbraun BS, Hackam DJ, Mollen KP. Peroxisome proliferator-activated receptor-y coactivator 1-α (PGC1α) protects against experimental murine colitis. J Biol Chem. 2016 May 6;291(19):10184-200. PMID: 26969166  
  10. Novak EA, Mollen KP. Mitochondrial dysfunction in inflammatory bowel disease. Front Cell Dev Biol. 2015 Oct 1;3:62. Review. PMID: 26484345  

NCBI bibliography.