Carolyn B. Coyne, PhD

  • Professor of Pediatrics, Immunology, and Microbiology and Molecular Genetics

Education & Training

  • Graduate School – University of North Carolina, Chapel Hill – PhD – Pharmacology
  • Post-Doctoral – University of Pennsylvania - Microbiology

Research Grants

NIH Grants:  R01, R56, R21 (2)

Research Summary

The research in my lab combines important aspects of virology, immunology, and cell biology to dissect various aspects of host-virus interactions, with a particular focus on polarized cell types. In particular, we focus on—

  • on the mechanisms by which enteroviruses have evolved to successfully circumnavigate the barriers presented by polarized cells to facilitate virus entry, replication, and spread
  • on the mechanisms utilized by enteroviruses to evade and/or suppress innate immune signaling
  • on the identification of novel regulators and components of the innate immune system
  • on the role of placental-specific microRNAs in antiviral signaling and the induction of autophagy at the maternal-fetal interface.

Representative Publications

  1. Good CA, Wells AI, and Coyne CB. Type III interferon signaling restricts enterovirus 71 infection of goblet cells. Science Advances 2019 Mar 6;5(3). PMID: 30854425.   
  2. Morosky S, Wells A, Lemon K, Evans E, Schamus S, Bakkenist CJ, Coyne CB. The neonatal Fc receptor is a pan-echovirus receptor. Proceedings of the National Academy of Science, 2019 2019 Feb 26;116(9):3758-3763. PMID: 30808762. 
  3. Zimmerman MG, Quicke KM, O'Neal JT, Arora N, Machiah D, Priyamvada L, Kauffman RC, Register E, Adekunle O, Swieboda D, Johnson EL, Cordes S, Haddad L, Chakraborty R, Coyne CB, Wrammert J, Suthar MS. Cross-Reactive Dengue Virus Antibodies Augment Zika Virus Infection of Human Placental Macrophages. Cell Host Microbe. 2018 Nov 14;24(5):731-742.e6. doi: 10.1016/j.chom.2018.10.008. PubMed PMID: 30439342.
  4. Freeman MC, Coyne CB, Green M, Williams JV, Silva LA. Emerging arboviruses and implications for pediatric transplantation: A review. Pediatr Transplant. 2018 Oct 19:e13303. doi: 10.1111/petr.13303. [Epub ahead of print] Review. PubMed PMID: 30338634.
  5. Coyne CB. Horsepox: Framing a dual use research of concern debate. PLoS Pathog. 2018 Oct 4;14(10):e1007344. doi: 10.1371/journal.ppat.1007344. eCollection 2018 Oct. PubMed PMID: 30286197; PubMed Central PMCID: PMC6171939
  6. Barrila J, Crabbé A, Yang J, Franco K, Nydam SD, Forsyth RJ, Davis RR, Gangaraju S, Ott CM, Coyne CB, Bissell MJ, Nickerson CA. Modeling Host-Pathogen Interactions in the Context of the Microenvironment: Three-Dimensional Cell Culture Comes of Age. Infect Immun. 2018 Oct 25;86(11). pii: e00282-18. doi: 10.1128/IAI.00282-18. Print 2018 Nov. Review. PubMed PMID: 30181350; PubMed
  7. Coyne CB. STING'ing Zika virus in neurons. Nat Microbiol. 2018 Sep;3(9):975-976. doi: 10.1038/s41564-018-0232-5. PubMed PMID: 30104582.
  8. Lanik WE, Mara MA, Mihi B, Coyne CB, Good M. Stem Cell-Derived Models of Viral Infections in the Gastrointestinal Tract. Viruses. 2018 Mar 10;10(3). pii: E124. doi: 10.3390/v10030124. Review. PubMed PMID: 29534451; PubMed Central PMCID: PMC5869517.
  9. Delorme-Axford E, Abernathy E, Lennemann NJ, Bernard A, Ariosa A, Coyne CB, Kirkegaard K, Klionsky DJ. The exoribonuclease Xrn1 is a post-transcriptional negative regulator of autophagy. Autophagy. 2018;14(5):898-912. doi: 10.1080/15548627.2018.1441648. Epub 2018 Mar 21. PubMed PMID: 29465287; PubMed Central PMCID: PMC6070002.​